Suppressive effects on cancer metastasis and tumor growth

The activation of lymphocytes (T lymphocytes) by low dose radiation has already been described. There are hopes that the activation of lymphocytes may possibly accentuate immune functions and enhance the ability to exclude pathogenic bacteria from the outside and foreign bodies (cancer, etc.) internally.

In this project, we focused on breeding hypertrophy of cancer metastasis and tumors and examined whether these were suppressed by radiation of low dose.

Using healthy mice in this experiment, we analyzed and evaluated the following:

(1) The conditions of tumor cells of squamous epithelium cancer origin that were transplanted to the large thigh hypodermic metastasized to the lung (Joint research with Tohoku University)
(2) The conditions of tumor cells of breast cancer origin that were transplanted to the large thigh hypodermic and the tumor enlarging in size. (University of Occupational and Environmental Health)

As a result, it was found that:

(1) In regard to cancer metastasis, the cancer metastasis rate falls by about 40% after one low dose irradiation of 15cGy.
(2) Tumors growth is suppressed significantly after irradiation in low doses of 4cGy each three times a week for four weeks.

Suppression of cancer metastasis by low dose irradiation



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